Popa Olivia M, Bojinca Mihai, Bojinca Violeta, Dutescu Monica I, Meirosu Mihaela, Caisan Ruxandra E, Ciofu Claudia, Bara Constantin, Popa Luis O
Department of Immunology and Pathophysiology, Faculty of Medicine, University Carol Davila, Bucharest 041914, Romania; E-Mails:
Int J Mol Sci. 2011;12(8):5052-9. doi: 10.3390/ijms12085052. Epub 2011 Aug 8.
Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The -857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05-2.57) and in combined haplotypes with the -238G/A and -308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.
肿瘤坏死因子α（TNF-α）是一种重要的促炎细胞因子，与银屑病关节炎的发病机制有关。我们对一组罗马尼亚银屑病关节炎患者与种族匹配的对照组进行了一项关于三种TNF-α基因多态性的病例对照关联研究。使用了第二组未分化脊柱关节炎患者，以寻找这两种风湿性疾病在遗传背景上的相似性。在我们的人群中，-857C/T多态性在个体水平上与银屑病关节炎易感性相关（p = 0.03，OR 1.65，95% CI 1.05 - 2.57），并且在与-238G/A和-308G/A单核苷酸多态性的组合单倍型中也相关。关于所研究的多态性和衍生单倍型，未发现与罗马尼亚患者未分化脊柱关节炎易感性有潜在关联。
