Department of Plant and Microbiology, University of California, Berkeley, CA 94720-3102, USA.
Wiley Interdiscip Rev RNA. 2010 Jul-Aug;1(1):47-59. doi: 10.1002/wrna.3. Epub 2010 May 6.
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens. In eukaryotes, regulation of message stability contributes significantly to the control of gene expression and plays a prominent role in the normal physiology of a cell as well as in its response to environmental and pathogenic stresses. Not surprisingly, emerging evidence indicates that there are significant interactions between the eukaryotic RNA turnover machinery and a wide variety of viruses. Interestingly, in many cases viruses have evolved mechanisms not only to evade eradication by these pathways, but also to manipulate them for enhanced viral replication and gene expression. Given our incomplete understanding of how many of these pathways are normally regulated, viruses should be powerful tools to help deconstruct the complex networks and events governing eukaryotic RNA stability.
控制细胞和病毒基因表达的能力，无论是全局的还是选择性的，对于成功的病毒感染至关重要，对于宿主的反应和消灭病原体也至关重要。在真核生物中，mRNA 稳定性的调节对基因表达的控制有重要贡献，并且在细胞的正常生理以及对环境和病原体应激的反应中发挥突出作用。毫不奇怪，新出现的证据表明，真核 RNA 周转机制与各种各样的病毒之间存在显著的相互作用。有趣的是，在许多情况下，病毒不仅进化出了逃避这些途径清除的机制，而且还进化出了操纵这些途径的机制，以促进病毒复制和基因表达。考虑到我们对这些途径通常是如何被调控的了解还不完整，病毒应该是强大的工具，可以帮助我们剖析控制真核 RNA 稳定性的复杂网络和事件。
