Narayanan Krishna, Makino Shinji
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555-1019, USA.
Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):732-41. doi: 10.1016/j.bbagrm.2012.12.003. Epub 2012 Dec 26.
Messenger RNA degradation is a fundamental cellular process that plays a critical role in regulating gene expression by controlling both the quality and the abundance of mRNAs in cells. Naturally, viruses must successfully interface with the robust cellular RNA degradation machinery to achieve an optimal balance between viral and cellular gene expression and establish a productive infection in the host. In the past several years, studies have discovered many elegant strategies that viruses have evolved to circumvent the cellular RNA degradation machinery, ranging from disarming the RNA decay pathways and co-opting the factors governing cellular mRNA stability to promoting host mRNA degradation that facilitates selective viral gene expression and alters the dynamics of host-pathogen interaction. This review summarizes the current knowledge of the multifaceted interaction between viruses and cellular mRNA degradation machinery to provide an insight into the regulatory mechanisms that influence gene expression in viral infections. This article is part of a Special Issue entitled: RNA Decay mechanisms.
信使核糖核酸（mRNA）降解是一个基本的细胞过程，它通过控制细胞内mRNA的质量和丰度，在调节基因表达中发挥关键作用。自然而然地，病毒必须成功地与强大的细胞RNA降解机制相互作用，以在病毒和细胞基因表达之间实现最佳平衡，并在宿主中建立有效的感染。在过去几年中，研究发现了许多病毒进化出的巧妙策略来规避细胞RNA降解机制，从解除RNA衰变途径的武装、拉拢控制细胞mRNA稳定性的因子，到促进宿主mRNA降解以利于选择性病毒基因表达并改变宿主-病原体相互作用的动态。本综述总结了目前关于病毒与细胞mRNA降解机制之间多方面相互作用的知识，以深入了解影响病毒感染中基因表达的调控机制。本文是名为“RNA衰变机制”的特刊的一部分。
