South African Research Chairs Initiative (SARChI), PTSD program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
Health Qual Life Outcomes. 2011 Sep 30;9:84. doi: 10.1186/1477-7525-9-84.
While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV.
The present study focused on HIV in the context of childhood trauma and its impact on functionality and Quality of Life (QoL) by evaluating 85 HIV-positive (48 with childhood trauma and 37 without) and 52 HIV-negative (21 with childhood trauma and 31 without) South African women infected with Clade C HIV. QoL was assessed using the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), the Patient's Assessment of Own Functioning Inventory (PAOFI), the Activities of Daily Living (ADL) scale and the Sheehan Disability Scale (SDS). Furthermore, participants were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Childhood Trauma Questionnaire (CTQ).
Subjects had a mean age of 30.1 years. After controlling for age, level of education and CES-D scores, analysis of covariance (ANCOVA) demonstrated significant individual effects of HIV status and childhood trauma on self-reported QoL. No significant interactional effects were evident. Functional limitation was, however, negatively correlated with CD4 lymphocyte count.
In assessing QoL in HIV-infected women, we were able to demonstrate the impact of childhood trauma on functional limitations in HIV.
虽然有许多关于 HIV 和功能障碍的已发表研究，但在早期虐待及其对 HIV 患者功能和生活质量（QoL）的影响方面的研究却很少。
本研究关注的是儿童时期创伤与 HIV 之间的关系及其对功能和生活质量（QoL）的影响，评估了 85 名 HIV 阳性（48 名有儿童期创伤，37 名没有）和 52 名 HIV 阴性（21 名有儿童期创伤，31 名没有）南非感染 Clade C HIV 的女性。使用生活质量满意度问卷（Q-LES-Q）、患者自身功能评估量表（PAOFI）、日常生活活动量表（ADL）和 Sheehan 残疾量表（SDS）评估生活质量。此外，还使用了流行病学研究中心抑郁量表（CES-D）和童年创伤问卷（CTQ）对参与者进行评估。
研究对象的平均年龄为 30.1 岁。在控制年龄、教育水平和 CES-D 评分后，协方差分析（ANCOVA）显示，HIV 状态和儿童期创伤对自我报告的生活质量有显著的个体影响。没有明显的相互作用影响。然而，功能障碍与 CD4 淋巴细胞计数呈负相关。
在评估 HIV 感染女性的生活质量时，我们能够证明儿童期创伤对 HIV 患者功能障碍的影响。
