人乳头瘤病毒（HPV）在头颈部癌症中的作用及 HPV 疫苗的综述。
The role of HPV in head and neck cancer and review of the HPV vaccine.
机构信息
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA.
出版信息
Prev Med. 2011 Oct;53 Suppl 1(Suppl 1):S5-S11. doi: 10.1016/j.ypmed.2011.08.001.
Abstract
Recent data demonstrate that human papillomavirus also plays a role in cancers other than ano-genital cancers, specifically head and neck cancers, and non-cancerous conditions such as recurrent respiratory papillomatosis. As more and more information about the role of infection in non-cervical diseases is amassed, additional questions about whether prophylactic human papillomavirus vaccines will effectively prevent these conditions are raised. This article reviews the epidemiology of oral human papillomavirus infection and the role of human papillomavirus in head and neck cancers. In addition, it will review the known clinical indications for human papillomavirus vaccination, and highlight other potential clinical targets for the vaccine that have not yet been demonstrated in clinical trials but for which there is biologic plausibility.
摘要
最近的数据表明，人乳头瘤病毒（HPV）除了肛门生殖器癌症外，还在其他癌症中发挥作用，特别是头颈部癌症，以及非癌症疾病，如复发性呼吸道乳头瘤病。随着越来越多关于感染在非宫颈疾病中的作用的信息被收集，人们提出了更多关于预防性 HPV 疫苗是否能有效预防这些疾病的问题。本文综述了口腔 HPV 感染的流行病学和 HPV 在头颈部癌症中的作用。此外，它还将回顾 HPV 疫苗接种的已知临床适应证，并强调其他尚未在临床试验中证明但具有生物学合理性的潜在临床疫苗靶点。
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