Pharmacy, Geneva University Hospitals (HUG), Geneva, Switzerland.
Talanta. 2011 Oct 15;85(5):2265-89. doi: 10.1016/j.talanta.2011.08.034. Epub 2011 Aug 24.
In the last decades, the number of patients receiving chemotherapy has considerably increased. Given the toxicity of cytotoxic agents to humans (not only for patients but also for healthcare professionals), the development of reliable analytical methods to analyse these compounds became necessary. From the discovery of new substances to patient administration, all pharmaceutical fields are concerned with the analysis of cytotoxic drugs. In this review, the use of methods to analyse cytotoxic agents in various matrices, such as pharmaceutical formulations and biological and environmental samples, is discussed. Thus, an overview of reported analytical methods for the determination of the most commonly used anticancer drugs is given.
在过去的几十年中，接受化疗的患者数量显著增加。鉴于细胞毒性药物对人类的毒性（不仅对患者，而且对医疗保健专业人员也是如此），开发可靠的分析方法来分析这些化合物变得非常必要。从新物质的发现到患者给药，所有制药领域都涉及细胞毒性药物的分析。在本文综述中，讨论了在各种基质中分析细胞毒性剂的方法，例如药物制剂以及生物和环境样品。因此，给出了用于测定最常用抗癌药物的已报道分析方法的概述。
