Pharmacy, Geneva University Hospitals (HUG), Geneva, Switzerland.
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.
Analyst. 2017 Jul 7;142(13):2273-2321. doi: 10.1039/c7an00367f. Epub 2017 May 31.
The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.
癌症患者的数量在不断增加，因此接受的化疗治疗种类也在增加。鉴于抗肿瘤药物的高反应性和高毒性，从药物开发到在废水中的消除，所有药物领域都需要分析方法；包括制剂质量控制、环境和人体暴露以及治疗药物监测。本文旨在综述不同基质中（如药物制剂、生物和环境样品）测定抗肿瘤药物的分析方法。将对报道的方法的适用性和性能进行批判性讨论，重点关注最常用的抗肿瘤药物。本综述仅考虑常规化合物和用于靶向治疗的小分子。
