Dromgoole S H, Maibach H I
Clinical Research and Development Department, Herbert Laboratories, Irvine, CA.
J Am Acad Dermatol. 1990 Jun;22(6 Pt 1):1068-78. doi: 10.1016/0190-9622(90)70154-a.
Reports in the literature of sensitization associated with many commonly used sunscreening agents including p-aminobenzoic acid (PABA), PABA derivatives, anthranilates, salicylates, cinnamates, benzophenones, and dibenzoylmethane derivatives are reviewed. Several of these case reports involved subjects with various photodermatoses, implicating enhanced sensitivity of the patient's skin to both light and chemicals. Despite the widespread use of sunscreens, the small number of published reports of contact and photocontact sensitization to these agents suggests that either such sensitization is less than commonly perceived or is underreported. Establishment of a registry for reporting adverse effects associated with sunscreening agents would help to characterize the incidence of sensitization.
本文综述了文献中关于与许多常用防晒剂相关的致敏报道，这些防晒剂包括对氨基苯甲酸（PABA）、PABA衍生物、邻氨基苯甲酸酯、水杨酸酯、肉桂酸酯、二苯甲酮和二苯甲酰甲烷衍生物。其中一些病例报告涉及患有各种光皮肤病的受试者，这表明患者皮肤对光和化学物质的敏感性增强。尽管防晒剂被广泛使用，但关于对这些制剂发生接触性和光接触性致敏的已发表报告数量较少，这表明要么这种致敏比通常认为的要少，要么是报告不足。建立一个用于报告与防晒剂相关不良反应的登记系统将有助于确定致敏的发生率。
