酵母和哺乳动物中的营养感应与雷帕霉素靶蛋白信号传导
Nutrient sensing and TOR signaling in yeast and mammals.
作者信息
González Asier, Hall Michael N
机构信息
Biozentrum, University of Basel, Basel, Switzerland.
Biozentrum, University of Basel, Basel, Switzerland
出版信息
EMBO J. 2017 Feb 15;36(4):397-408. doi: 10.15252/embj.201696010. Epub 2017 Jan 17.
Abstract
Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases.
摘要
使细胞生长与营养物质供应相协调对于细胞存活至关重要。进化上保守的TOR（雷帕霉素靶蛋白）响应营养物质，尤其是氨基酸，来控制细胞生长。作为细胞生长的核心调控因子，mTOR（哺乳动物雷帕霉素靶蛋白）与包括癌症、肥胖症和糖尿病在内的多种疾病有关。在这里，我们综述了在出芽酵母和哺乳动物中营养物质供应是如何被感知并传递给TOR的。更好地理解营养物质供应是如何传递给TOR的，可能会为治疗与mTOR相关的疾病带来新的策略。
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