Department of Herbology, College of Oriental Medicine, Kyung-Hee University, Seoul 130-701, Republic of Korea.
J Ethnopharmacol. 2011 Nov 18;138(2):398-403. doi: 10.1016/j.jep.2011.09.028. Epub 2011 Sep 22.
Chelidonium majus (CM) has traditionally been used for treatment of various inflammatory diseases including atopic dermatitis (AD). However its action on atopic dermatitis (AD) is unclear. Therefore, we investigated the effect of CM on AD using NC/Nga mice as an AD model.
The effect of CM on 1-chloro-2,4-dinitrobenzene (DNCB) induced NC/Nga mice was evaluated by examining skin symptom severity, itching behavior, ear thickness, levels of serum immunoglobulin E (IgE), tumor necrosis factor-α (TNF-α), and interlukin-4 (IL-4), skin histology.
The CM significantly reduced the total clinical severity score, itching behavior, ear thickness and the level of serum IgE in AD mouse model. CM not only decreased TNF-α but also IL-4.
These results suggest that CM may be a potential therapeutic modality for AD.
水飞蓟（CM）传统上被用于治疗各种炎症性疾病，包括特应性皮炎（AD）。然而，其对特应性皮炎（AD）的作用尚不清楚。因此，我们使用 NC/Nga 小鼠作为 AD 模型来研究 CM 对 AD 的作用。
通过检查皮肤症状严重程度、瘙痒行为、耳朵厚度、血清免疫球蛋白 E（IgE）、肿瘤坏死因子-α（TNF-α）和白细胞介素-4（IL-4）水平以及皮肤组织学，评估 CM 对 1-氯-2,4-二硝基苯（DNCB）诱导的 NC/Nga 小鼠的影响。
CM 可显著降低 AD 小鼠模型的总临床严重程度评分、瘙痒行为、耳朵厚度和血清 IgE 水平。CM 不仅降低了 TNF-α，还降低了 IL-4。
这些结果表明，CM 可能是治疗 AD 的一种潜在治疗方法。
