Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
J Thorac Oncol. 2012 Jan;7(1):183-7. doi: 10.1097/JTO.0b013e3182340abb.
The aim of this study was to analyze the association between changes in quality of life and survival after lung cancer surgery.
In a prospective population-based cohort study, quality of life was estimated using the Medical Outcomes Study 36-Item Short Form (SF-36) questionnaire before and 6 months after lung cancer surgery. Cox regression models adjusting for potential confounding factors were used to analyze the association between baseline SF-36 scores and changes in SF-36 scores and survival.
A SF-36 questionnaire was distributed to 249 patients at baseline. We excluded 79 patients with histopathology other than primary lung cancer. Six months after surgery, 11 patients died and 18 patients did not return the questionnaire, leaving 141 patients with data from both baseline and follow-up. The baseline SF-36 physical component summary score was significantly associated with survival, but the baseline mental component was not. Declines of 10% in the physical and mental component summary scores from baseline to follow-up were associated with an 18 and 13% higher risk of death, respectively.
Changes in quality of life during 6 months after surgery for lung cancer may provide prognostic information regarding survival.
本研究旨在分析肺癌手术后生活质量变化与生存之间的关系。
在一项前瞻性基于人群的队列研究中，使用医疗结局研究 36 项简短调查问卷（SF-36）在肺癌手术前和 6 个月后评估生活质量。使用调整潜在混杂因素的 Cox 回归模型来分析基线 SF-36 评分与 SF-36 评分变化以及生存之间的关系。
在基线时向 249 名患者分发了 SF-36 问卷。我们排除了 79 名组织病理学非原发性肺癌的患者。手术后 6 个月，11 名患者死亡，18 名患者未返回问卷，留下了 141 名基线和随访数据均有的患者。基线 SF-36 生理成分综合评分与生存显著相关，但心理成分没有。与基线相比，生理和心理成分综合评分在随访期间下降 10%，分别与死亡风险增加 18%和 13%相关。
肺癌手术后 6 个月期间生活质量的变化可能提供与生存相关的预后信息。
