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用于预测胸段肺癌手术术后生存预期的深度堆叠稀疏自动编码器

Deep stacked sparse auto-encoders for prediction of post-operative survival expectancy in thoracic lung cancer surgery.

作者信息

Saber Iraji Mohammad

机构信息

Payame Noor University, Faculty of Engineering, Department of Computer Engineering and Information Technology, Tehran, Iran.

出版信息

J Appl Biomed. 2019 Mar;17(1):75. doi: 10.32725/jab.2018.007. Epub 2019 Jan 10.

Abstract

Lung cancer is the leading cause of cancer death in men and women. The prognostic value of survival after lung cancer surgery has an important role in decision-making for surgeons and patients. The combination of clinical features and CT scan information for diagnosis, treatment and survival of patients with lung cancer increases the accuracy of prediction using machine learning. Therefore, creating a computer intelligent method with low error and high accuracy to predict survival is an important challenge, and it is beneficial for decreasing mortality from lung cancer, and for planning treatment. In this work, we implemented a deep stacked sparse auto-encoder (DSSAE) approach on a thoracic surgery data set for 470 patients, and our results contributing to deep learning based on 16 features were more precise than other suggested techniques for predicting post-operative survival expectancy in thoracic lung cancer surgery. The proposed method achieved a sensitivity of 94%, specificity of 82.86% and g-mean of 88.25%.

摘要

肺癌是男性和女性癌症死亡的主要原因。肺癌手术后生存的预后价值在外科医生和患者的决策中具有重要作用。将临床特征与CT扫描信息相结合用于肺癌患者的诊断、治疗和生存分析,可提高机器学习预测的准确性。因此,创建一种低误差、高精度的计算机智能方法来预测生存率是一项重大挑战,这有助于降低肺癌死亡率并规划治疗方案。在这项工作中,我们对470例患者的胸外科数据集实施了深度堆叠稀疏自编码器(DSSAE)方法,基于16个特征的深度学习结果比其他用于预测胸段肺癌手术术后生存预期的建议技术更为精确。该方法的灵敏度达到94%,特异度为82.86%,g均值为88.25%。

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