Bjørndal Kristine, Larsen Stine R, Therkildsen Marianne H, Kristensen Claus A, Charabi Birgitte, Andersen Elo, Overgaard Jens, Schytte Sten, Pedersen Henrik B, Andersen Lisbeth J, Johansen Jørgen, Godballe Christian
a Department of ENT-HNS , Odense University Hospital , Odense , Denmark ;
b Department of Pathology , Odense University Hospital , Odense , Denmark ;
Acta Oncol. 2016;55 Suppl 1:19-22. doi: 10.3109/0284186X.2015.1114671. Epub 2016 Jan 11.
To compare incidence, histology, treatment modalities, disease stages, and outcome in elderly patients (≥70 years) compared to younger (<70 years).
From the national Danish salivary gland carcinoma database, 871 patients diagnosed with a primary salivary gland carcinoma from January 1990 to December 2005 were identified. Variables necessary for statistical analyses were extracted from the database.
The younger patients have a significantly better crude, disease-specific and recurrence-free survival than the elderly ones. In univariate analysis, significantly more patients in the young group were WHO performance status 0 and in disease stage I + II, and they presented with significantly more histological low grade tumors. In multivariate analysis, chronological age seemed to be of no prognostic significance to salivary gland carcinoma patients as opposed to performance status, disease stage and histological grade.
Salivary gland carcinoma patients over the age of 70 years have a poor prognosis compared to younger patients, which can be explained by higher disease stages, more histological high grade subtypes and a poorer performance status at the time of diagnosis.
比较老年患者（≥70岁）与年轻患者（<70岁）在发病率、组织学、治疗方式、疾病分期及预后方面的差异。
从丹麦国家唾液腺癌数据库中，识别出1990年1月至2005年12月期间诊断为原发性唾液腺癌的871例患者。从数据库中提取统计分析所需的变量。
年轻患者的粗生存率、疾病特异性生存率和无复发生存率明显优于老年患者。单因素分析显示，年轻组中WHO体能状态为0且处于疾病I+II期的患者明显更多，且组织学低级别肿瘤的比例明显更高。多因素分析表明，与体能状态、疾病分期和组织学分级不同，实际年龄对唾液腺癌患者似乎没有预后意义。
与年轻患者相比，70岁以上的唾液腺癌患者预后较差，这可以通过更高的疾病分期、更多的组织学高级别亚型以及诊断时较差的体能状态来解释。
