Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Health Economics and Health Care Management, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Qual Life Res. 2012 Sep;21(7):1205-16. doi: 10.1007/s11136-011-0024-3. Epub 2011 Oct 5.
To analyse the psychometric properties of the EQ-5D in German stroke survivors undergoing neurological rehabilitation.
The EQ-5D, the Hospital Anxiety and Depression Scale (HADS) and the Stroke Impact Scale (SIS) were completed before (210 subjects) and after (183 subjects) a patient education programme in seven rehabilitation clinics in Bavaria, Germany. A postal follow-up was conducted after 6 months. Acceptance, validity, reliability and responsiveness of the EQ-5D were tested. The SIS subscales were used as external anchors to classify the patients into change groups between the measurements.
The proportion of missing answers ranged from 4.7 to 8.6%. Between 16 and 19% reported no problems in any EQ-5D dimension. At baseline, correlations between EQ-5D index and the SIS subscales ranged from 0.15 (communication) to 0.60 (mobility). Correlations with the EQ VAS were slightly smaller. All scores were reliable in test-retest with intraclass correlations ranging from 0.67 to 0.81. EQ-5D index and EQ VAS were consistently responsive only to improvements in health, showing small- to medium effect sizes (0.27-0.42).
The EQ-5D has shown reasonable validity, reliability and, more limited, responsiveness in stroke patients with mild to moderate limitations of functional status, allowing it to be used in clinical trials in rehabilitation.
分析接受神经康复治疗的德国中风幸存者的 EQ-5D 心理测量特性。
在巴伐利亚州的七家康复诊所中进行了一项患者教育计划之前（210 名受试者）和之后（183 名受试者），完成了 EQ-5D、医院焦虑和抑郁量表（HADS）和中风影响量表（SIS）。在 6 个月后进行了邮寄随访。测试了 EQ-5D 的接受度、有效性、可靠性和反应性。使用 SIS 分量表作为外部锚将患者分类为测量之间的变化组。
缺失回答的比例范围为 4.7%至 8.6%。在任何 EQ-5D 维度上，有 16%至 19%的人报告没有问题。在基线时，EQ-5D 指数与 SIS 分量表之间的相关性范围从 0.15（沟通）到 0.60（移动性）。与 EQ VAS 的相关性稍小。所有分数在测试-重测中均具有可靠性，组内相关系数范围为 0.67 至 0.81。EQ-5D 指数和 EQ VAS 仅对健康状况的改善具有一致性的反应性，显示出小至中等的效应大小（0.27-0.42）。
EQ-5D 在功能状态轻度至中度受限的中风患者中显示出合理的有效性、可靠性，以及更有限的反应性，允许其在康复临床试验中使用。
