Division of Biology, California Institute of Technology, Pasadena, CA, USA.
Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):79-102. doi: 10.1002/wsbm.162. Epub 2011 Oct 4.
Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function.
调控基因回路使干细胞和祖细胞能够检测和处理发育信号，并做出不可逆的命运决定。为了深入了解祖细胞中 T 细胞命运决定的基因回路，我们从文献中发现的基因和连接生成了一个更新的 T 淋巴细胞发育基因调控网络。这种重建使我们能够识别决定 T 细胞命运的候选调控基因回路元件。在这里，我们研究了这些回路在促进决策过程不同方面的作用，并讨论了进一步探究其结构和功能的实验。
