Victor Babes Institute, Bucharest, Romania Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
J Cell Mol Med. 2011 Dec;15(12):2569-74. doi: 10.1111/j.1582-4934.2011.01461.x.
We advance the hypothesis that the telocyte might be the cell of origin of both PEComas (perivascular epithelioid cell tumours) and GISTs (gastro-intestinal and extra-gastrointestinal stromal tumours). The hypothesis is supported by data from the literature reporting that both PEComas and GISTs, as well as telocytes, share the expression of several markers. These data were supplemented by original immunohistochemical tests on selected series. Specifically: (1) Melanoma markers (Melan A, MiTF) typical of PEComas are expressed by a substantial fraction of GISTs. A fraction of GISTs was also found positive for CD63, a tetraspanin protein originally described in melanomas and marking exosomes. (2) c-KIT (CD117), proper of the vast majority of GISTs, can be expressed by PEComas (as well as by telocytes). (3) Markers described in telocytes (CD34, S-100, smooth muscle actin and vascular endothelial growth factor) have been reported as positive in cases of PEComas and GISTs. Telocytes show distinctive ultrastructural features with thin, extended, telopodes and are likely involved in inter-cellular signalling via paracrine secretion as well as by shed vesicles and exosomes. These cells have been described in many locations (cavitary and non-cavitary organs) and might display potentialities of a wide spectrum of differentiation (and function). In conclusion we propose that telocytes could be the common cells of origin for both PEComas and GISTs.
我们提出假说，认为始基细胞可能是上皮样血管周细胞瘤（PEComa）和胃肠外间质瘤（GIST）的起源细胞。这一假说得到了文献数据的支持，这些数据表明 PEComa 和 GIST 以及始基细胞都表达了几种标志物。这些数据还通过对选定系列的原始免疫组织化学测试得到了补充。具体来说：（1）黑色素瘤标志物（Melan A、MiTF）是 PEComa 的典型标志物，在很大一部分 GIST 中表达。一部分 GIST 也被发现对 CD63 呈阳性，CD63 是一种最初在黑色素瘤中描述的四跨膜蛋白，标志着外泌体。（2）c-KIT（CD117）是绝大多数 GIST 的特征，可以被 PEComa（以及始基细胞）表达。（3）在始基细胞中描述的标志物（CD34、S-100、平滑肌肌动蛋白和血管内皮生长因子）在 PEComa 和 GIST 病例中被报道为阳性。始基细胞具有独特的超微结构特征，具有细长的、延伸的端足，可能通过旁分泌以及脱落小泡和外泌体参与细胞间信号传递。这些细胞已在许多部位（腔隙和非腔隙器官）中被描述，并可能显示出广泛的分化（和功能）潜能。总之，我们提出始基细胞可能是 PEComa 和 GIST 的共同起源细胞。
