Grant D N, Benson J, Cozad M J, Whelove O E, Bachman S L, Ramshaw B J, Grant D A, Grant S A
Department of Biological Engineering, University of Missouri-Columbia, Columbia, MO 65211, USA.
J Mater Sci Mater Med. 2011 Dec;22(12):2803-12. doi: 10.1007/s10856-011-4449-6. Epub 2011 Oct 7.
Polypropylene mesh materials have been utilized in hernia surgery for over 40 years. However, they are prone to degradation due to the body's aggressive foreign body reaction, which may cause pain or complications, forcing mesh removal from the patient. To mitigate these complications, gold nanomaterials were attached to polypropylene mesh in order to improve cellular response. Pristine samples of polypropylene mesh were exposed to hydrogen peroxide/cobalt chloride solutions to induce formation of surface carboxyl functional groups. Gold nanoparticles were covalently linked to the mesh. Scanning electron microscopy confirmed the presence of gold nanoparticles. Differential scanning calorimetry and mechanical testing confirmed that the polypropylene did not undergo any significantly detrimental changes in physicochemical properties. A WST-1 cell culture study showed an increase in cellularity on the gold nanoparticle-polypropylene mesh as compared to pristine mesh. This study showed that biocompatibility of polypropylene mesh may be improved via the conjugation of gold nanoparticles.
聚丙烯网状材料已在疝修补手术中使用了40多年。然而，由于人体强烈的异物反应，它们容易降解，这可能会导致疼痛或并发症，迫使从患者体内取出网片。为了减轻这些并发症，将金纳米材料附着在聚丙烯网片上以改善细胞反应。将聚丙烯网片的原始样品暴露于过氧化氢/氯化钴溶液中以诱导表面羧基官能团的形成。金纳米颗粒与网片共价连接。扫描电子显微镜证实了金纳米颗粒的存在。差示扫描量热法和力学测试证实聚丙烯的物理化学性质没有发生任何明显的有害变化。一项WST-1细胞培养研究表明，与原始网片相比，金纳米颗粒-聚丙烯网片上的细胞数量有所增加。这项研究表明，通过金纳米颗粒的共轭可以提高聚丙烯网片的生物相容性。
