Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy.
J Endocrinol Invest. 2012 Sep;35(8):748-53. doi: 10.3275/8011. Epub 2011 Oct 4.
We assessed the associations between pancreatic fat accumulation and other fat compartments, including liver fat and visceral adipose tissue as well as insulin resistance and other metabolic abnormalities in obese individuals.
We studied 42 Caucasian adults with obesity [20 men and 22 women; mean body mass index (BMI) 35.2±4 kg/m(2)], who had no history of liver diseases or excessive alcohol consumption, in which subcutaneous, visceral, liver, and pancreatic fat contents were quantified by an in-opposed-phase magnetic resonance imaging (MRI) technique.
Compared with patients in the lower tertile (<5.6%, no.=15), those in the upper tertile of liver fat content had more visceral adipose tissue, greater insulin resistance and had higher values of BMI, blood pressure, triglycerides and lower HDL-cholesterol and adiponectin. Notably, pancreatic fat accumulation also significantly increased across tertiles of liver fat content. In univariate analysis, the strongest correlates of pancreatic fat were visceral and liver fat contents (r=0.80 and r=0.54, p<0.001- 0.0001, respectively). Pancreatic fat accumulation was also moderately associated with insulin resistance and other metabolic syndrome features. However, when adjusted for age, gender and visceral adipose tissue, the associations of pancreatic fat accumulation with liver fat and other metabolic abnormalities were no longer significant.
There are significant associations between pancreatic fat accumulation and liver fat content as well as insulin resistance and other metabolic abnormalities in obese, but otherwise healthy, individuals. However, these associations are largely mediated by the amount of visceral adipose tissue.
我们评估了肥胖个体中胰腺脂肪积累与其他脂肪区室（包括肝脂肪和内脏脂肪组织）以及胰岛素抵抗和其他代谢异常之间的相关性。
我们研究了 42 名白种肥胖成年人（20 名男性和 22 名女性；平均体重指数（BMI）为 35.2±4kg/m²），他们没有肝脏疾病或过度饮酒史，通过反相位磁共振成像（MRI）技术定量了皮下、内脏、肝脏和胰腺的脂肪含量。
与肝脂肪含量较低三分位（<5.6%，n=15）的患者相比，肝脂肪含量较高三分位的患者内脏脂肪组织更多，胰岛素抵抗更严重，BMI、血压、甘油三酯更高，HDL-胆固醇和脂联素水平更低。值得注意的是，胰腺脂肪积累也随着肝脂肪含量的三分位增加而显著增加。在单变量分析中，胰腺脂肪的最强相关因素是内脏和肝脂肪含量（r=0.80 和 r=0.54，p<0.001-0.0001）。胰腺脂肪积累与胰岛素抵抗和其他代谢综合征特征也有中度相关性。然而，当调整年龄、性别和内脏脂肪组织后，胰腺脂肪积累与肝脂肪和其他代谢异常的相关性不再显著。
在肥胖但其他方面健康的个体中，胰腺脂肪积累与肝脂肪含量以及胰岛素抵抗和其他代谢异常之间存在显著相关性。然而，这些相关性在很大程度上是由内脏脂肪组织的量介导的。
