自噬、营养与免疫学。
Autophagy, nutrition and immunology.
机构信息
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Mol Aspects Med. 2012 Feb;33(1):2-13. doi: 10.1016/j.mam.2011.09.001. Epub 2011 Oct 1.
Abstract
Turnover of cellular components in lysosomes or autophagy is an essential mechanism for cellular quality control. Added to this cleaning role, autophagy has recently been shown to participate in the dynamic interaction of cells with the surrounding environment by acting as a point of integration of extracellular cues. In this review, we focus on the relationship between autophagy and two types of environmental factors: nutrients and pathogens. We describe their direct effect on autophagy and discuss how the autophagic reaction to these stimuli allows cells to accommodate the requirements of the cellular response to stress, including those specific to the immune responses.
摘要
溶酶体或自噬体中细胞成分的周转率是细胞质量控制的一个基本机制。除了清洁作用外，自噬最近还被证明通过作为细胞与周围环境动态相互作用的整合点参与其中，从而参与细胞与周围环境的动态相互作用。在这篇综述中，我们重点关注自噬与两种类型的环境因素之间的关系：营养物质和病原体。我们描述了它们对自噬的直接影响，并讨论了自噬对这些刺激的反应如何使细胞适应细胞应激反应的要求，包括对免疫反应的特异性要求。
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本文引用的文献
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