Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Denmark; Centre of Functionally Integrative Neuroscience, Aarhus University, Denmark.
Perelman School of Medicine at The University of Pennsylvania, Philadelphia, USA.
Parkinsonism Relat Disord. 2014 Jan;20(1):22-6. doi: 10.1016/j.parkreldis.2013.09.006. Epub 2013 Sep 19.
Dopaminergic medication administered to ameliorate motor symptoms of Parkinson's disease is associated with impulse control disorders, such as pathological gambling, hypersexuality, compulsive buying, and binge eating. Studies indicate a prevalence of impulse control disorders in Parkinson's disease of 6-16%.
To estimate the prevalence of impulsive and compulsive behaviors among Danish patients with Parkinson's disease and to explore the relation of such behavioral disorders to depression and personality.
490 patients with Parkinson's disease (303 males), identified through the National Danish Patient Registry, were evaluated with: 1) the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease; 2) the Geriatric Depression Scale; and 3) the NEO-Personality Inventory.
176 (35.9%) patients reported impulsive and compulsive behaviors sometime during Parkinson's disease (current symptoms in 73, 14.9%). Hereof, 114 (23.3%) reported multiple behavioral symptoms. Patients with behavioral symptoms were significantly younger, were younger at PD onset, had longer disease duration, displayed more motor symptoms, and received higher doses of dopaminergic medication than patients without behavioral symptoms. Furthermore, they reported significantly more depressive symptoms and scored significantly higher on neuroticism and lower on both agreeableness and conscientiousness than patients without behavioral symptoms.
A history of impulsive and compulsive behaviors are common in Danish patients with Parkinson's disease and have clinical correlates that may allow identification of patients at risk for developing these behaviors.
为改善帕金森病的运动症状而给予的多巴胺能药物与冲动控制障碍有关，例如病理性赌博、性欲亢进、强迫性购买和暴食症。研究表明，帕金森病患者中冲动控制障碍的患病率为 6-16%。
评估丹麦帕金森病患者冲动和强迫行为的患病率，并探讨这些行为障碍与抑郁和人格的关系。
通过国家丹麦患者登记处确定了 490 名帕金森病患者（303 名男性），并对其进行了以下评估：1）帕金森病冲动-强迫障碍问卷；2）老年抑郁量表；3）NEO 人格量表。
176 名（35.9%）患者在帕金森病期间报告了冲动和强迫行为（目前症状为 73 名，占 14.9%）。其中，114 名（23.3%）报告了多种行为症状。有行为症状的患者明显更年轻，帕金森病发病年龄更小，病程更长，运动症状更多，接受的多巴胺能药物剂量更高。此外，他们报告的抑郁症状明显更多，神经质得分明显更高，而宜人性和尽责性得分明显更低。
在丹麦帕金森病患者中，冲动和强迫行为的病史很常见，并且具有临床相关性，这可能有助于识别有发生这些行为风险的患者。
