Department of Pathology Section on Comparative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA.
Exp Neurol. 2012 Jan;233(1):87-94. doi: 10.1016/j.expneurol.2011.09.026. Epub 2011 Sep 24.
The focus of the review is on the behavioral and physiological manifestations of stress versus depression. The purpose of the review is to evaluate the conceptual approach of using stress models as surrogates for depression. Social stress and depression have many characteristics in common and promote each other. Both have adverse effects on social relationships and the quality of life, and increase risk of other diseases. However, they are not the same constructs. In human and nonhuman primates, the behavior and neurobiology of stressed individuals differ from that of depressed individuals. Some similarities in stress physiology in socially stressed and depressed individuals have been used to support the use of stressed animals as models of depression, and much has been learned from stress models of depression. However, the studies reviewed here also suggest that the depressed state also has different characteristics than the stressed state, and studying the differences may be important to furthering our understanding of each of these constructs as well as their mutual relationship.
本次综述的重点是压力与抑郁的行为和生理表现。综述的目的是评估将压力模型用作抑郁替代物的概念方法。社会压力和抑郁有许多共同特征，并相互促进。两者都对人际关系和生活质量产生不利影响，并增加患其他疾病的风险。然而，它们不是相同的结构。在人类和非人类灵长类动物中，压力个体的行为和神经生物学与抑郁个体不同。社会压力个体和抑郁个体在应激生理学上的一些相似性被用于支持使用应激动物作为抑郁模型，并且从抑郁应激模型中学到了很多东西。然而，这里回顾的研究也表明，抑郁状态也与应激状态有不同的特征，研究这些差异对于进一步了解这两种结构以及它们之间的相互关系可能很重要。
