Department of Medicine, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
Immunol Invest. 2011;40(7-8):786-808. doi: 10.3109/08820139.2011.605196.
The interaction of pathogenic Cryptococcus species with their various hosts is somewhat unique compared to other fungal pathogens such as Aspergillus fumigatus and Candida albicans. Cryptococcus shares an intimate association with host immune cells, leading to enhanced intracellular growth. Furthermore, unlike most other fungal pathogens, the signs and symptoms of cryptococcal disease are typically self-inflicted by the host during the host's attempt to clear this invader from sensitive organ systems such as the central nervous system. In this review, we will summarize the story of host-Cryptococcus interactions to date and explore strategies to exploit the current knowledge for treatment of cryptococcal infections.
与其他真菌病原体（如烟曲霉和白色念珠菌）相比，致病Cryptococcus 物种与其各种宿主的相互作用有些独特。Cryptococcus 与宿主免疫细胞密切相关，导致细胞内生长增强。此外，与大多数其他真菌病原体不同，隐球菌病的体征和症状通常是宿主在试图清除中枢神经系统等敏感器官系统中的这种入侵物时自行造成的。在这篇综述中，我们将总结迄今为止宿主-Cryptococcus 相互作用的故事，并探讨利用现有知识治疗隐球菌感染的策略。
