Heung Lena J
Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
J Fungi (Basel). 2017 Sep;3(3). doi: 10.3390/jof3030035. Epub 2017 Jul 2.
species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The development of more effective therapies may depend on our understanding of the cellular and molecular mechanisms by which the host promotes sterilizing immunity against the fungus. This review will highlight our current knowledge of how , primarily the species , is sensed by the mammalian host and how subsequent signaling pathways direct the anti-cryptococcal response by effector cells of the innate immune system.
隐球菌属是在环境中发现的包膜真菌，吸入肺部后主要在免疫功能低下的宿主中引起疾病。即使采用当代抗真菌治疗方案，隐球菌病患者的发病率和死亡率仍然很高。开发更有效的治疗方法可能取决于我们对宿主促进针对真菌的杀菌免疫的细胞和分子机制的理解。本综述将重点介绍我们目前对哺乳动物宿主如何感知隐球菌属，以及随后的信号通路如何指导先天免疫系统效应细胞的抗隐球菌反应的认识。
