Papahadjopoulos D, Gabizon A
Cancer Research Institute, University of California, San Francisco 94143.
Prog Clin Biol Res. 1990;343:85-93.
Recent work has revealed some new and important characteristics of liposomes: Inclusion of certain glycolipids within liposomes composed of phosphatidylcholine or sphingomyelin and cholesterol drastically prolongs the circulation time and reduces their uptake by liver and spleen. Concomitantly, their accumulation in several implanted tumors is substantially increased. These studies suggest that controlling the circulation time of liposomes and limiting their non-specific uptake by the Reticuloendothelial system (RES) opens up new opportunities for achieving specific targeting to tumors in vivo, with both diagnostic and therapeutic possibilities.
在由磷脂酰胆碱或鞘磷脂与胆固醇组成的脂质体内包含某些糖脂，可显著延长其循环时间，并减少肝脏和脾脏对它们的摄取。与此同时，它们在几种植入肿瘤中的蓄积显著增加。这些研究表明，控制脂质体的循环时间并限制其被网状内皮系统（RES）非特异性摄取，为在体内实现对肿瘤的特异性靶向开辟了新机会，具有诊断和治疗的可能性。
