Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research (CSIR), Mahatma Gandhi Marg, Lucknow 226001 (U.P), India.
J Proteomics. 2011 Nov 18;74(12):2713-22. doi: 10.1016/j.jprot.2011.09.024. Epub 2011 Oct 2.
Humans are often exposed to a variety of pollutants that contribute to an individual's risk for diseases including cancer. Animal, cell cultures and epidemiological lines of evidence demonstrate that exposure to various environmental pollutants including pesticides are associated with increasing frequency of cancers. Organophosphates, organochlorines, carbamates, pyrethroids, the major groups of pesticides, have been reported to be carcinogenic in various models. However, the results of these studies are still controversial, nevertheless, their mechanism of action is clear. Therefore, new strategies in toxicological research are needed for efficient screening for adverse effects of pesticides on complex living systems. Biomarkers can be employed to identify causal associations and to make better quantitative and qualitative estimates of those associations at relevant levels of exposure. This will enable us to deepen our understanding of mechanism behind their carcinogenic potential. Deciphering the associations between pesticide exposure and cancer, following toxicoproteomics application, will be useful in the development of potential predictive biomarkers of pesticide induced carcinogenicity. Therefore, the thrust of this article was to review the risk of cancer due to pesticide exposure and significant toxicoproteomic-based studies conducted so far, to identify the novel molecules as possible biomarkers for cancer following pesticide exposure.
人类经常接触到各种污染物，这些污染物会增加个体患癌症等疾病的风险。动物、细胞培养和流行病学研究表明，接触各种环境污染物，包括农药，与癌症发病率的增加有关。有机磷、有机氯、氨基甲酸酯、拟除虫菊酯是农药的主要几大类型，在各种模型中都被报道具有致癌性。然而，这些研究的结果仍存在争议，但它们的作用机制是明确的。因此，需要在毒理学研究中采用新策略，以有效筛选农药对复杂生命系统的不良影响。生物标志物可用于确定因果关系，并在相关暴露水平上对这些关系进行更好的定量和定性估计。这将使我们能够更深入地了解其致癌潜力背后的机制。在应用毒蛋白组学之后，阐明农药暴露与癌症之间的关联，将有助于开发农药诱导致癌性的潜在预测性生物标志物。因此，本文的重点是综述由于农药暴露而导致癌症的风险，以及迄今为止进行的重要基于毒蛋白组学的研究，以确定农药暴露后可能作为癌症生物标志物的新型分子。
