Department of Physiology, University of Granada, Granada, Spain.
Eur J Nutr. 2012 Oct;51(7):791-9. doi: 10.1007/s00394-011-0257-5. Epub 2011 Oct 12.
Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.
The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q(10) (CoQ(10)) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.
The participants were classified in two groups: CoQ(10) group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.
Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ(10) during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ(10) prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ(10) supplementation reduced creatinine production.
CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.
剧烈运动可导致肌肉损伤，引起自由基和促炎介质大量产生。
本研究旨在首次同时确定口服辅酶 Q10（CoQ10）补充剂是否可以预防与剧烈运动相关的促炎介质和氧化应激过度表达。
将参与者分为 CoQ10 组（CG）和安慰剂组（PG）。体能测试包括一项持续 50 公里的恒定跑步，其中结合了多种高强度运动（山地跑和超耐力跑），且一直处于攀爬状态。
运动与 TNF-α、IL-6、8-羟基-2'-脱氧鸟苷（8-OHdG）和异前列烷水平的升高相关，表明炎症和氧化应激的程度。在运动过程中口服 CoQ10 补充剂是有效的，可以减少氧化应激（减少膜氢过氧化物、8-OHdG 和异前列烷的产生，增加过氧化氢酶和总抗氧化状态），从而维持细胞完整性。所得数据还表明，CoQ10 可防止运动后 TNF-α 的过度表达，同时增加 sTNF-RII，从而限制 TNF 的促炎作用。此外，CoQ10 补充剂可减少肌酸酐的产生。
剧烈运动前补充 CoQ10 可降低氧化应激并调节炎症信号，从而减少随后的肌肉损伤。
