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几种药用植物对临床分离的人类致龋病原体的抗菌活性——一项体外研究

Antimicrobial Activity of Few Medicinal Plants against Clinically Isolated Human Cariogenic Pathogens-An In Vitro Study.

作者信息

Jebashree H Shyla, Kingsley S Jayasurya, Sathish Emmanuel S, Devapriya D

机构信息

Department of Plant Biology and Biotechnology, School of Life Sciences, Loyola College, Chennai 600 034, India.

出版信息

ISRN Dent. 2011;2011:541421. doi: 10.5402/2011/541421. Epub 2011 Jun 8.

DOI:10.5402/2011/541421
PMID:21991479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3169913/
Abstract

Hexane, ethyl acetate, ethanol and methanol extracts of Psidium guajava, Terminalia chebula, Mimusops elengi and Achyranthes aspera were tested against the dental caries causing bacteria Streptococcus mutans and fungus Candida albicans isolated from caries infected patients. All the four extracts of P. guajava showed activity against both S. mutans and C. albicans. Maximum zone of inhibition was observed in ethyl acetate of P. guajava. The four extracts of T. chebula and M. elengi showed antibacterial activity against S. mutans. M. elengi extracts and ethanol extract of T. chebula did not show any antifungal activity against C. albicans. Except for the hexane extract of A. aspera, the other three extracts showed activity against the tested microbes. The ethyl acetate P. guajava leaf extract showed the minimum inhibitory concentration (MIC) against S. mutans to be <0.076 mg/mL in both MHB and BHI. The P. guajava ethyl acetate extract was subjected to GC-MS.

摘要

对番石榴、诃子、人心果和牛膝的己烷、乙酸乙酯、乙醇和甲醇提取物进行了测试，以对抗从龋齿感染患者中分离出的致龋细菌变形链球菌和真菌白色念珠菌。番石榴的所有四种提取物均对变形链球菌和白色念珠菌有活性。在番石榴的乙酸乙酯中观察到最大抑菌圈。诃子和人心果的四种提取物对变形链球菌有抗菌活性。人心果提取物和诃子的乙醇提取物对白色念珠菌没有任何抗真菌活性。除了牛膝的己烷提取物外，其他三种提取物对受试微生物有活性。番石榴叶乙酸乙酯提取物在MHB和BHI中对变形链球菌的最低抑菌浓度（MIC）均<0.076 mg/mL。对番石榴乙酸乙酯提取物进行了GC-MS分析。

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