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Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases.益生菌微生物对白细胞介素-10的调节在胃肠道炎症性疾病中的重要性。
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本文引用的文献

1
Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice.利用超氧化物歧化酶和过氧化氢酶产生的乳酸菌治疗三硝基苯磺酸诱导的小鼠克罗恩病。
J Biotechnol. 2011 Feb 10;151(3):287-93. doi: 10.1016/j.jbiotec.2010.11.008. Epub 2010 Dec 16.
2
Monoassociation with probiotic Lactobacillus delbrueckii UFV-H2b20 stimulates the immune system and protects germfree mice against Listeria monocytogenes infection.与益生菌德氏乳杆菌 UFV-H2b20 的单关联可刺激免疫系统并保护无菌小鼠免受李斯特菌感染。
Med Microbiol Immunol. 2011 Feb;200(1):29-38. doi: 10.1007/s00430-010-0170-1. Epub 2010 Sep 14.
3
Rectal administration of Lactobacillus casei DG modifies flora composition and Toll-like receptor expression in colonic mucosa of patients with mild ulcerative colitis.鼠李糖乳杆菌 DG 经直肠给药可改变轻度溃疡性结肠炎患者结肠黏膜菌群组成和 Toll 样受体表达。
Dig Dis Sci. 2011 Apr;56(4):1178-87. doi: 10.1007/s10620-010-1384-1. Epub 2010 Aug 25.
4
The application of probiotic fermented milks in cancer and intestinal inflammation.益生菌发酵乳在癌症和肠道炎症中的应用。
Proc Nutr Soc. 2010 Aug;69(3):421-8. doi: 10.1017/S002966511000159X. Epub 2010 Jun 16.
5
Risk assessment of genetically modified lactic acid bacteria using the concept of substantial equivalence.利用实质等同性概念对转基因乳酸菌进行风险评估。
Curr Microbiol. 2010 Dec;61(6):590-5. doi: 10.1007/s00284-010-9657-7. Epub 2010 May 7.
6
Saccharomyces cerevisiae strain UFMG 905 protects against bacterial translocation, preserves gut barrier integrity and stimulates the immune system in a murine intestinal obstruction model.酿酒酵母 UFMG 905 菌株可预防细菌易位，保护肠道屏障的完整性，并在小鼠肠梗阻模型中刺激免疫系统。
Arch Microbiol. 2010 Jun;192(6):477-84. doi: 10.1007/s00203-010-0574-8. Epub 2010 May 1.
7
An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model.表达重组白细胞介素-10 的乳球菌菌株的鼻腔内给药调节小鼠模型中的急性过敏性气道炎症。
Clin Exp Allergy. 2010 Oct;40(10):1541-51. doi: 10.1111/j.1365-2222.2010.03502.x.
8
Intestinal and immunological effects of daily oral administration of Lactobacillus salivarius CECT5713 to healthy adults.每日口服唾液乳杆菌 CECT5713 对健康成年人的肠道和免疫影响。
Anaerobe. 2010 Jun;16(3):195-200. doi: 10.1016/j.anaerobe.2010.02.001. Epub 2010 Feb 14.
9
Toll-like receptors as therapeutic targets in gastrointestinal diseases.Toll 样受体作为胃肠道疾病的治疗靶点。
Expert Opin Ther Targets. 2010 Apr;14(4):347-68. doi: 10.1517/14728221003642027.
10
Fermented Maesil (Prunus mume) with probiotics inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice.含益生菌的发酵青梅抑制NC/Nga小鼠特应性皮炎样皮肤损伤的发展。
Vet Dermatol. 2010 Apr;21(2):184-91. doi: 10.1111/j.1365-3164.2009.00796.x. Epub 2010 Feb 5.

益生菌微生物对白细胞介素-10的调节在胃肠道炎症性疾病中的重要性。

Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases.

作者信息

de Moreno de Leblanc Alejandra, Del Carmen Silvina, Zurita-Turk Meritxell, Santos Rocha Clarissa, van de Guchte Maarten, Azevedo Vasco, Miyoshi Anderson, Leblanc Jean Guy

机构信息

Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de Tucumán, T4000ILC Tucumán, Argentina.

出版信息

ISRN Gastroenterol. 2011;2011:892971. doi: 10.5402/2011/892971. Epub 2011 Feb 8.

DOI:10.5402/2011/892971
PMID:21991534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3168568/
Abstract

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of one of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of gastrointestinal inflammatory disease through their immune-modulating properties. A special emphasis will be placed on the critical role of the anti-inflammatory cytokine IL-10, and a brief overview of the uses of genetically engineered LAB that produce this important immune response mediator will also be discussed. Thus, this paper will demonstrate the critical role that IL-10 plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment.

摘要

乳酸菌（LAB）是一类异质的微生物群体，天然存在于许多食物中，并具有广泛的治疗特性。本文旨在概述目前关于乳酸菌和其他益生菌微生物通过其免疫调节特性参与预防和治疗胃肠道炎症性疾病的机制之一的不断扩展的知识。将特别强调抗炎细胞因子IL-10的关键作用，还将简要概述产生这种重要免疫反应介质的基因工程乳酸菌的用途。因此，本文将证明IL-10在胃肠道炎症性疾病中所起的关键作用以及益生菌如何用于其治疗。