益生菌微生物对白细胞介素-10的调节在胃肠道炎症性疾病中的重要性。
Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases.
作者信息
de Moreno de Leblanc Alejandra, Del Carmen Silvina, Zurita-Turk Meritxell, Santos Rocha Clarissa, van de Guchte Maarten, Azevedo Vasco, Miyoshi Anderson, Leblanc Jean Guy
机构信息
Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, San Miguel de Tucumán, T4000ILC Tucumán, Argentina.
出版信息
ISRN Gastroenterol. 2011;2011:892971. doi: 10.5402/2011/892971. Epub 2011 Feb 8.
Abstract
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of one of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of gastrointestinal inflammatory disease through their immune-modulating properties. A special emphasis will be placed on the critical role of the anti-inflammatory cytokine IL-10, and a brief overview of the uses of genetically engineered LAB that produce this important immune response mediator will also be discussed. Thus, this paper will demonstrate the critical role that IL-10 plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment.
摘要
乳酸菌（LAB）是一类异质的微生物群体，天然存在于许多食物中，并具有广泛的治疗特性。本文旨在概述目前关于乳酸菌和其他益生菌微生物通过其免疫调节特性参与预防和治疗胃肠道炎症性疾病的机制之一的不断扩展的知识。将特别强调抗炎细胞因子IL-10的关键作用，还将简要概述产生这种重要免疫反应介质的基因工程乳酸菌的用途。因此，本文将证明IL-10在胃肠道炎症性疾病中所起的关键作用以及益生菌如何用于其治疗。
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