Liu Fang, Zhang Haipeng, Fan Lina, Yu Qi, Wang Siqiao
Hangzhou Linping District Maternal and Child Health Care Hospital, Hangzhou, China.
Chengdong College, Northeast Agricultural University, Harbin, China.
Medicine (Baltimore). 2024 Dec 13;103(50):e40931. doi: 10.1097/MD.0000000000040931.
Atopic dermatitis (AD) is a prevalent inflammatory skin condition that commonly occurs in children. More and more scientific evidence suggests that gut microbiota plays an important role in the pathogenesis of AD, whereas there is no article providing a comprehensive summary and analysis. We aimed to analyze documents on AD and gut microbiota and identify hotspots and development trends in this field.
Articles and reviews in the field of AD and gut microbiota from January 1, 1988 to October 20, 2024 were obtained from the Web of Science Core Collection database. Biblioshiny was utilized for evaluating and visualizing the core authors, journals, countries, documents, trend topics, and hotspots in this field.
Among 1672 documents, it indicated that the number of annual publications generally increased. The United States had the highest production, impact, and international collaboration. Journal of Allergy and Clinical Immunology was the journal of the maximum publications. Based on keyword co-occurrence and clustering analysis, "stratum-corneum lipids," "probiotics," "prebiotics," "fecal microbiota transplantation," "phage therapy," "short chain fatty-acids," "biologic therapy," and "skin inflammation" represented current trend topics. The pathological and molecular mechanisms and associated therapeutic methods for AD and gut microbiota were the research hotspots. The incorporation of microbiota-based therapies alongside conventional treatments can contribute to better clinical outcomes.
We highlighted that gut microbiota may exacerbate symptoms of AD through various aspects, including immunity, metabolites, and neuroendocrine pathways. More efforts are required to investigate the safety and efficacy of gut microbial management methods for the prevention and treatment of AD.
特应性皮炎（AD）是一种常见的炎症性皮肤病，多见于儿童。越来越多的科学证据表明肠道微生物群在AD的发病机制中起重要作用，但尚无文章对此进行全面总结和分析。我们旨在分析关于AD和肠道微生物群的文献，并确定该领域的热点和发展趋势。
从Web of Science核心合集数据库中获取1988年1月1日至2024年10月20日期间AD和肠道微生物群领域的文章和综述。利用Biblioshiny评估和可视化该领域的核心作者、期刊、国家、文献、趋势主题和热点。
在1672篇文献中，年度出版物数量总体呈上升趋势。美国的发文量、影响力和国际合作程度最高。《过敏与临床免疫学杂志》是发文量最多的期刊。基于关键词共现和聚类分析，“角质层脂质”“益生菌”“益生元”“粪便微生物群移植”“噬菌体疗法”“短链脂肪酸”“生物疗法”和“皮肤炎症”代表了当前的趋势主题。AD与肠道微生物群的病理和分子机制以及相关治疗方法是研究热点。将基于微生物群的疗法与传统治疗方法相结合可带来更好的临床效果。
我们强调肠道微生物群可能通过免疫、代谢产物和神经内分泌途径等多个方面加重AD症状。需要进一步努力研究肠道微生物群管理方法在预防和治疗AD方面的安全性和有效性。
