Grange Rachel, Lanvin Thomas, Hsieh Chia-Lung, Pu Ye, Psaltis Demetri
Biomed Opt Express. 2011 Sep 1;2(9):2532-9. doi: 10.1364/BOE.2.002532. Epub 2011 Aug 2.
We demonstrate that second-harmonic radiation imaging probes are efficient biomarkers for imaging in living tissue. We show that 100 nm and 300 nm BaTiO(3) nanoparticles used as contrast markers could be detected through 50 μm and 120 μm of mouse tail tissue in vitro or in vivo. Experimental results and Monte-Carlo simulations are in good agreement.
我们证明，二次谐波辐射成像探针是用于活体组织成像的有效生物标志物。我们表明，用作对比标记的100纳米和300纳米钛酸钡（BaTiO₃）纳米颗粒，在体外或体内均可透过50微米和120微米的小鼠尾部组织被检测到。实验结果与蒙特卡洛模拟结果吻合良好。
