Yang Yi, Li Xiang, Wang Tianheng, Kumavor Patrick D, Aguirre Andres, Shung Kirk K, Zhou Qifa, Sanders Melinda, Brewer Molly, Zhu Quing
Biomed Opt Express. 2011 Sep 1;2(9):2551-61. doi: 10.1364/BOE.2.002551. Epub 2011 Aug 5.
Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in Stages III or IV due to the lack of reliable symptoms, as well as the lack of efficacious screening techniques. Detection before the malignancy spreads or at the early stage would greatly improve the survival and benefit patient health. In this report, we present an integrated optical coherence tomography (OCT), ultrasound (US) and photoacoustic imaging (PAI) prototype endoscopy system for ovarian tissue characterization. The overall diameter of the prototype endoscope is 5 mm which is suitable for insertion through a standard 5-12.5mm endoscopic laparoscopic port during minimally invasive surgery. It consists of a ball-lensed OCT sample arm probe, a multimode fiber having the output end polished at 45 degree angle so as to deliver the light perpendicularly for PAI, and a high frequency ultrasound transducer with 35MHz center frequency. System characterizations of OCT, US and PAI are presented. In addition, results obtained from ex vivo porcine and human ovarian tissues are presented. The optical absorption contrast provided by PAI, the high resolution subsurface morphology provided by OCT, and the deeper tissue structure imaged by US demonstrate the synergy of the combined endoscopy and the superior performance of this hybrid device over each modality alone in ovarian tissue characterization.
卵巢癌在妇科癌症中的生存率最低，这是因为其主要在III期或IV期才被诊断出来，原因在于缺乏可靠的症状以及有效的筛查技术。在恶性肿瘤扩散之前或早期进行检测将极大地提高生存率并有益于患者健康。在本报告中，我们展示了一种用于卵巢组织表征的集成光学相干断层扫描（OCT）、超声（US）和光声成像（PAI）的原型内窥镜系统。该原型内窥镜的整体直径为5毫米，适合在微创手术期间通过标准的5 - 12.5毫米内窥镜腹腔镜端口插入。它由一个球透镜OCT样品臂探头、一个输出端以45度角抛光以便垂直传输光用于PAI的多模光纤以及一个中心频率为35MHz的高频超声换能器组成。展示了OCT、US和PAI的系统特性。此外，还展示了从离体猪和人卵巢组织获得的结果。PAI提供的光吸收对比度、OCT提供的高分辨率亚表面形态以及US成像的更深组织结构证明了组合内窥镜的协同作用以及该混合设备在卵巢组织表征方面相对于单一模态的卓越性能。
