Jiang Jinsheng, Yuan Chuqi, Zhang Jiaxi, Xie Zhuojun, Xiao Jiaying
Department of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Front Bioeng Biotechnol. 2023 Jan 26;11:1136005. doi: 10.3389/fbioe.2023.1136005. eCollection 2023.
The inadequacy of existing colorectal imaging tools has significantly obstructed the efficient detection of colorectal cancer. To address this issue, this work presents the cross-scale endoscopic imaging of rectal tumors with a combined photoacoustic/ultrasound tomography system and wide-field optical microscopy. This multimodal system combines the merits of centimeter-scale deep penetration, multi-spectral imaging, cross-scale imaging ability, low system cost, and 360° view in a single modality. Results indicated that the proposed system could reliably depict the location of the cancer invasion depth spectroscopically with indocyanine green The tumor angiogenesis can be well identified in the wide-field optical imaging mode, which helps to localize the tumors and guide the following photoacoustic/ultrasound scan. This work may facilitate the accurate characterization of colorectal cancer and promote the clinical translation of photoacoustic-based colorectal endoscopy.
现有结直肠成像工具的不足严重阻碍了结直肠癌的有效检测。为解决这一问题，本研究利用光声/超声断层扫描系统和宽视野光学显微镜对直肠肿瘤进行跨尺度内镜成像。这种多模态系统在单一模态中结合了厘米级深度穿透、多光谱成像、跨尺度成像能力、低系统成本和360°视野的优点。结果表明，所提出的系统可以通过吲哚菁绿可靠地在光谱上描绘癌症浸润深度的位置。在宽视野光学成像模式下可以很好地识别肿瘤血管生成，这有助于定位肿瘤并指导后续的光声/超声扫描。本研究可能有助于结直肠癌的准确表征，并促进基于光声的结直肠内镜的临床转化。
