Wanek Justin, Teng Pang-Yu, Albers John, Blair Norman P, Shahidi Mahnaz
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago IL, 60612, USA.
Biomed Opt Express. 2011 Sep 1;2(9):2562-8. doi: 10.1364/BOE.2.. Epub 2011 Aug 9.
The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the current study is to report a novel technique for assessment of the inner retinal metabolic rate of oxygen (MO(2)) by combined measurements of retinal blood flow and vascular oxygen tension (PO(2)) in rat. The application of this technology has the potential to broaden knowledge of retinal oxygen dynamics and advance understanding of disease pathophysiology.
视网膜内层细胞的代谢功能依赖于视网膜循环所供应的营养物质和氧气。评估视网膜组织的活力和功能需要了解氧气的输送和消耗速率。本研究的目的是报告一种通过联合测量大鼠视网膜血流和血管氧分压（PO₂）来评估视网膜内层氧代谢率（MO₂）的新技术。这项技术的应用有可能拓宽对视网膜氧动力学的认识，并促进对疾病病理生理学的理解。
