Yazici Kemal Utku, Yazici Ipek Percinel, Ustundag Bilal
Department of Child and Adolescent Psychiatry, Firat University Medical Faculty, Elazig, Turkey.
Department of Biochemistry, Firat University Medical Faculty, Elazig, Turkey.
Clin Psychopharmacol Neurosci. 2019 Feb 28;17(1):105-112. doi: 10.9758/cpn.2019.17.1.105.
In this study, we aimed to evaluate the serum hepcidin levels in attention deficit hyperactivity disorder (ADHD) patients that were newly diagnosed with no history of psychotropic drugs.
A total of 70 ADHD patients and 69 healthy controls were enrolled in our study. During the diagnosis, the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version were applied. The sociodemographic data form, Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating Scale, and Conners' Rating Scales-Revised: Long Form were used for the clinical evaluation. Serum hepcidin levels were measured and compared between the groups.
No significant difference between the groups in terms of age (=0.533) and gender (=0.397) was determined. In addition, the groups did not differ significantly for the other sociodemographic variables recorded. Serum hepcidin levels were found to be significantly higher in the patients with ADHD than healthy controls (=0.019).
To the best of our knowledge, this study is the first to evaluate the total serum hepcidin levels in ADHD patients. Our study findings may suggest that high levels of hepcidin may cause iron dysregulation in ADHD patients. However, further studies are required to establish a definite conclusion.
在本研究中，我们旨在评估新诊断且无精神药物使用史的注意力缺陷多动障碍（ADHD）患者的血清铁调素水平。
本研究共纳入70例ADHD患者和69例健康对照。诊断过程中，应用了《学龄儿童情感障碍和精神分裂症量表 - 当前及终生版》。社会人口学数据表格、基于图尔盖DSM - IV的儿童和青少年行为障碍筛查及评定量表以及修订版康纳斯评定量表：长式量表用于临床评估。测量并比较两组的血清铁调素水平。
两组在年龄（=0.533）和性别（=0.397）方面未发现显著差异。此外，记录的其他社会人口学变量在两组间也无显著差异。发现ADHD患者的血清铁调素水平显著高于健康对照（=0.019）。
据我们所知，本研究是首次评估ADHD患者的血清总铁调素水平。我们的研究结果可能表明，高铁调素水平可能导致ADHD患者铁代谢失调。然而，需要进一步研究以得出明确结论。
