出芽短梗霉水凝胶可促进间充质干细胞向高氧化应激伤口输送。
Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds.
机构信息
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
出版信息
Macromol Biosci. 2011 Nov 10;11(11):1458-66. doi: 10.1002/mabi.201100180. Epub 2011 Oct 12.
Abstract
Cell-based therapies for wound repair are limited by inefficient delivery systems that fail to protect cells from the acute inflammatory environment. Here, a biomimetic hydrogel system is described that is based on the polymer pullulan, a carbohydrate glucan known to exhibit potent antioxidant capabilities. It is shown that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high-oxidative-stress environments. The results suggest that glucan hydrogel systems may prove beneficial for progenitor-cell-based approaches to skin regeneration.
摘要
基于细胞的伤口修复疗法受到低效传递系统的限制，这些系统无法保护细胞免受急性炎症环境的影响。本文描述了一种基于聚合物普鲁兰多糖的仿生水凝胶系统，该多糖是一种具有强大抗氧化能力的碳水化合物葡聚糖。结果表明，普鲁兰多糖水凝胶是一种有效的细胞传递系统，可以提高间充质干细胞在高氧化应激环境中的存活率和植入率。这些结果表明，葡聚糖水凝胶系统可能有益于基于祖细胞的皮肤再生方法。
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