伴有严重慢性活动性 EBV 感染的侵袭性外周 CD70 阳性 T 细胞淋巴瘤。
Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection.
机构信息
Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, The Methodist Hospital, Houston, Texas 77030, USA.
出版信息
Pediatr Blood Cancer. 2012 Oct;59(4):758-61. doi: 10.1002/pbc.23352. Epub 2011 Oct 12.
Abstract
Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma.
摘要
严重慢性活动性 EBV 感染（CAEBV）是潜伏 EBV 感染的罕见并发症，主要发生在 T 或 NK 细胞中。CAEBV 相关 T 细胞淋巴组织增生性疾病（LPD）由多克隆病变和侵袭性淋巴瘤组成。本文报告了这样 1 例患者，并发现该原发性 CAEBV 相关 T 细胞淋巴瘤表达 CD70，对 CD70 特异性 T 细胞杀伤敏感，提示 CD70 可能成为 CAEBV 相关 T 细胞淋巴瘤的潜在免疫治疗靶点。
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