Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, The Methodist Hospital, Houston, Texas 77030, USA.
Pediatr Blood Cancer. 2012 Oct;59(4):758-61. doi: 10.1002/pbc.23352. Epub 2011 Oct 12.
Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma.
严重慢性活动性 EBV 感染（CAEBV）是潜伏 EBV 感染的罕见并发症，主要发生在 T 或 NK 细胞中。CAEBV 相关 T 细胞淋巴组织增生性疾病（LPD）由多克隆病变和侵袭性淋巴瘤组成。本文报告了这样 1 例患者，并发现该原发性 CAEBV 相关 T 细胞淋巴瘤表达 CD70，对 CD70 特异性 T 细胞杀伤敏感，提示 CD70 可能成为 CAEBV 相关 T 细胞淋巴瘤的潜在免疫治疗靶点。
