IRCCS Fondazione Don Carlo Gnocchi, 20132 Milan, Italy.
School of Medicine, Università Vita-Salute San Raffaele, 20132 Milan, Italy.
Int J Mol Sci. 2022 Dec 16;23(24):16033. doi: 10.3390/ijms232416033.
Aging is associated with an increasing burden of morbidity, especially for cardiovascular diseases (CVDs). General cardiovascular risk factors, ischemic heart diseases, heart failure, arrhythmias, and cardiomyopathies present a significant prevalence in older people, and are characterized by peculiar clinical manifestations that have distinct features compared with the same conditions in a younger population. Remarkably, the aging heart phenotype in both healthy individuals and patients with CVD reflects modifications at the cellular level. An improvement in the knowledge of the physiological and pathological molecular mechanisms underlying cardiac aging could improve clinical management of older patients and offer new therapeutic targets.
衰老是发病率负担增加的一个因素，特别是心血管疾病（CVDs）。一般心血管危险因素、缺血性心脏病、心力衰竭、心律失常和心肌病在老年人中具有较高的患病率，其临床表现与年轻人群中的相同疾病有明显不同。值得注意的是，健康个体和 CVD 患者的衰老心脏表型反映了细胞水平的改变。改善心脏衰老的生理和病理分子机制的认识可以改善老年患者的临床管理，并提供新的治疗靶点。
