Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity (CINIMA), Academic Medical Centre (AMC), University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands; E-Mails:
Viruses. 2009 Dec;1(3):647-56. doi: 10.3390/v1030647. Epub 2009 Oct 30.
HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.
HCoV-NL63 是一种新近鉴定的呼吸道病毒。由于目前缺乏动物模型，其发病机制尚未完全阐明。在这里，我们通过检测时间相关的 HCoV-NL63 抗体水平，来研究恒河猴在生活中是否会感染 HCoV-NL63。对这些动物进行了长达 7 年至 19 年的随访，在 3 只动物的随访过程中观察到抗体水平急剧上升，提示其发生了 HCoV-NL63 的自然感染。
