Chiu Susan S, Chan Kwok Hung, Chu Ka Wing, Kwan See Wai, Guan Yi, Poon Leo Lit Man, Peiris J S M
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Clin Infect Dis. 2005 Jun 15;40(12):1721-9. doi: 10.1086/430301. Epub 2005 May 10.
Human coronavirus NL63 (HCoV-NL63) is a recently discovered human coronavirus found to cause respiratory illness in children and adults that is distinct from the severe acute respiratory syndrome (SARS) coronavirus and human coronaviruses 229E (HCoV-229E) and OC43 (HCoV-OC43).
We investigated the role that HCoV-NL63, HCoV-OC43, and HCoV-229E played in children hospitalized with fever and acute respiratory symptoms in Hong Kong during the period from August 2001 through August 2002.
Coronavirus infections were detected in 26 (4.4%) of 587 children studied; 15 (2.6%) were positive for HCoV-NL63, 9 (1.5%) were positive for HCoV-OC43, and 2 (0.3%) were positive for HCoV-229E. In addition to causing upper respiratory disease, we found that HCoV-NL63 can present as croup, asthma exacerbation, febrile seizures, and high fever. The mean age (+/- standard deviation [SD]) of the infected children was 30.7 +/- 19.8 months (range, 6-57 months). The mean maximum temperature (+/- SD) for the 12 children who were febrile was 39.3 degrees C +/- 0.9 degrees C, and the mean total duration of fever (+/- SD) for all children was 2.6 +/- 1.2 days (range, 1-5 days). HCoV-NL63 infections were noted in the spring and summer months of 2002, whereas HCoV-OC43 infection mainly occurred in the fall and winter months of 2001. HCoV-NL63 viruses appeared to cluster into 2 evolutionary lineages, and viruses from both lineages cocirculated in the same season.
HCoV-NL63 is a significant pathogen that contributes to the hospitalization of children, and it was estimated to have caused 224 hospital admissions per 100,000 population aged < or = 6 years each year in Hong Kong.
人冠状病毒NL63（HCoV-NL63）是一种最近发现的人冠状病毒，可导致儿童和成人出现呼吸道疾病，它与严重急性呼吸综合征（SARS）冠状病毒以及人冠状病毒229E（HCoV-229E）和OC43（HCoV-OC43）不同。
我们调查了2001年8月至2002年8月期间在香港因发热和急性呼吸道症状住院的儿童中，HCoV-NL63、HCoV-OC43和HCoV-229E所起的作用。
在587名接受研究的儿童中，有26名（4.4%）检测到冠状病毒感染；15名（2.6%）HCoV-NL63呈阳性，9名（1.5%）HCoV-OC43呈阳性，2名（0.3%）HCoV-229E呈阳性。除了引起上呼吸道疾病外，我们还发现HCoV-NL63可表现为哮吼、哮喘加重、热性惊厥和高热。受感染儿童的平均年龄（±标准差[SD]）为30.7±19.8个月（范围为6 - 57个月）。12名发热儿童的平均最高体温（±SD）为39.3℃±0.9℃，所有儿童发热的平均总持续时间（±SD）为2.6±1.2天（范围为1 - 5天）。2002年的春季和夏季发现了HCoV-NL63感染，而HCoV-OC43感染主要发生在2001年的秋季和冬季。HCoV-NL63病毒似乎聚集成2个进化谱系，两个谱系的病毒在同一季节共同流行。
HCoV-NL63是导致儿童住院的一种重要病原体，据估计在香港每年每10万名年龄≤6岁的人群中可导致224例住院病例。
