病毒和细胞功能的矛盾相互作用。
Paradoxical interplay of viral and cellular functions.
机构信息
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1, Cantoblanco, Madrid 28049, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona 08036, Spain.
出版信息
Viruses. 2011 Mar;3(3):272-277. doi: 10.3390/v3030272. Epub 2011 Mar 15.
Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
一些细胞编辑功能可以限制某些病毒的复制，但有助于完成其他病毒的生命周期。最近的一项研究确定了 RNA 型 1 腺苷脱氨酶作用的同种型（ADAR1）是胚胎发生所必需的，并且是多种重要的 RNA 病毒病原体的限制因子。关键细胞功能在先天免疫中的双重含义，针对病毒，或者，矛盾的是，作为病毒复制的介质，可以根据 François Jacob 几十年前提出的一般进化中的病毒 - 宿主共同进化和修补的概念来解释。
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