木糖醇口香糖对学龄前儿童口腔变形链球菌水平的影响：随机分组试验。
Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomised trial.
机构信息
Department of Oral Health Sciences, Nihon University School of Dentistry, Tokyo, Japan.
出版信息
Int Dent J. 2011 Oct;61(5):274-80. doi: 10.1111/j.1875-595X.2011.00073.x.
OBJECTIVES
To assess the influence of xylitol chewing gum consumption on mutans streptococci level of 3-4 years old Japanese preschoolers.
METHODS
248 participants were examined regarding caries-related factors at baseline and were followed up at 6, 9, and 12 months after the baseline: assessors were blinded, subjects were open labelled and blocked parallel randomised; 142 were selected to use xylitol gum for 3 months (from months 6 to 9) and 106 were controls.
RESULTS
161 participants were analysed (xylitol n = 76, control n = 85). Nineteen caries-related variables, including xylitol gum consumption, were analysed for any association with the main outcome, plaque mutans streptococci scores development within the intervention period, by logistic regression. Six showed statistically significant associations by univariate analysis (P < 0.05). However, only xylitol gum consumption remained a significant negative association (P < 0.05) by multiple analyses. Interestingly, over 10% xylitol group children experienced diarrhoea, which was larger than previous investigations.
CONCLUSION
Xylitol gum is effective in avoiding increased plaque mutans streptococci in young children.
目的
评估 3-4 岁日本学龄前儿童咀嚼木糖醇口香糖对变形链球菌水平的影响。
方法
248 名参与者在基线时接受了与龋齿相关因素的检查，并在基线后 6、9 和 12 个月进行了随访：评估者为盲法，受试者为开放标签和分组平行随机；142 名被选者在 3 个月（第 6 至 9 个月）内使用木糖醇口香糖，106 名被选者为对照组。
结果
对 161 名参与者（木糖醇组 n = 76，对照组 n = 85）进行了分析。通过逻辑回归分析了 19 个与龋齿相关的变量，包括木糖醇口香糖的使用情况，与主要结局（干预期间菌斑变形链球菌评分的发展）之间的任何关联。单变量分析显示 6 个变量具有统计学意义（P < 0.05）。然而，只有木糖醇口香糖的使用情况在多变量分析中仍然存在显著的负相关（P < 0.05）。有趣的是，超过 10%的木糖醇组儿童出现腹泻，这一比例高于以往的调查。
结论
木糖醇口香糖可有效预防儿童菌斑变形链球菌的增加。
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