乙基乙烯基酮在细菌试验中的诱变性和遗传毒性。

Mutagenicity and genotoxicity of ethylvinyl ketone in bacterial tests.

作者信息

Deininger C, Eder E, Neudecker T, Hoffman C

机构信息

Institute of Toxicology, University of Würzburg, FRG.

出版信息

J Appl Toxicol. 1990 Jun;10(3):167-71. doi: 10.1002/jat.2550100305.

DOI:10.1002/jat.2550100305

PMID:2199554

Abstract

The mutagenic and genotoxic effects of ethylvinyl ketone were investigated. This alpha, beta-unsaturated carbonyl compound is widely distributed in the environment, in particular in food. Whereas ethylvinyl ketone shows only weak genotoxicity in the SOS Chromotest with Escherichia coli PQ37, it was distinctly mutagenic per se in the Salmonella preincubation assay with TA100. Using SKF 525 (an inhibitor of microsomal monooxygenase) and trichloropropene oxide (an inhibitor of epoxide hydrolase) we found indication for additional activation via epoxidation by S9 mix. The need for further investigation of the genotoxic, mutagenic and carcinogenic effects of this compound is strongly indicated.

摘要

研究了乙烯基乙基酮的诱变和遗传毒性作用。这种α,β-不饱和羰基化合物在环境中广泛分布，尤其是在食品中。虽然乙烯基乙基酮在大肠杆菌PQ37的SOS色变试验中仅表现出微弱的遗传毒性，但在TA100的沙门氏菌预培养试验中其本身具有明显的诱变性。使用SKF 525（一种微粒体单加氧酶抑制剂）和环氧三氯丙烷（一种环氧化物水解酶抑制剂），我们发现有迹象表明该化合物可通过S9混合物进行环氧化而进一步活化。强烈表明需要对该化合物的遗传毒性、诱变性和致癌性作用进行进一步研究。