Life Science Research Center, Beihua University, Jilin 132013, China.
J Agric Food Chem. 2011 Nov 9;59(21):11543-7. doi: 10.1021/jf203170k. Epub 2011 Oct 13.
Proanthocyanidins are naturally occurring compounds that are widely available in many kinds of plants; particularly, the grape seeds are a rich source of proanthocyanidins. Grape seed proanthocyanidins (GSPs) have been demonstrated to possess a wide range of health beneficial properties. This study was carried out to elucidate the molecular mechanisms involved in the antitumor therapeutic and immunomodulating effects of GSPs through in vivo and in vitro models. The results showed that GSPs could significantly inhibit the growth of Sarcoma 180 tumor cells in vivo and remarkably increase thymus and spleen weight of Sarcoma 180-bearing mice and upgrade the secretion level of tumor necrosis factor-α (TNF-α) in serum. Moreover, GSPs could stimulate lymphocyte transformation, enhance lysosomal enzyme activity and phagocytic capability of peritoneal macrophages, and remarkably promote the production of TNF-α. These results suggested that GSPs could improve functional activation of the immune system, and the antitumor effects of GSPs were achieved by immunostimulating properties.
原花青素是一种天然存在的化合物，广泛存在于许多植物中；特别是葡萄籽是原花青素的丰富来源。葡萄籽原花青素（GSPs）已被证明具有广泛的有益健康的特性。本研究通过体内和体外模型，阐明了 GSPs 在抗肿瘤治疗和免疫调节作用中的分子机制。结果表明，GSPs 能显著抑制体内肉瘤 180 肿瘤细胞的生长，显著增加肉瘤 180 荷瘤小鼠的胸腺和脾脏重量，并提高血清中肿瘤坏死因子-α（TNF-α）的分泌水平。此外，GSPs 能刺激淋巴细胞转化，增强腹腔巨噬细胞溶酶体酶活性和吞噬能力，并显著促进 TNF-α的产生。这些结果表明，GSPs 能改善免疫系统的功能激活，GSPs 的抗肿瘤作用是通过免疫刺激特性实现的。
