Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Mult Scler. 2011 Dec;17(12):1405-11. doi: 10.1177/1352458511425366. Epub 2011 Oct 13.
Observational studies suggest that adequate vitamin D nutrition may reduce the risk of MS and affect the course of the disease. Inherent limitations in these studies, however, preclude a causal interpretation. Randomized controlled clinical trials are the next step to addressing whether vitamin D prevents MS or can favorably affect the course and progression of MS. Here we briefly review the current literature on vitamin D and MS, both as a risk factor and potential treatment for MS with a focus on the issues and challenges in designing prevention and treatment clinical trials.
观察性研究表明，充足的维生素 D 营养可能会降低多发性硬化症的风险，并影响疾病的进程。然而，这些研究存在固有局限性，因此不能对此做出因果关系的解释。随机对照临床试验是下一步，旨在确定维生素 D 是否可以预防多发性硬化症，或者是否可以对多发性硬化症的病程和进展产生有利影响。在此，我们简要回顾了目前关于维生素 D 与多发性硬化症的文献，既关注了维生素 D 作为多发性硬化症的风险因素，也关注了维生素 D 作为多发性硬化症潜在治疗手段的相关内容，重点讨论了设计预防和治疗临床试验所面临的问题和挑战。
