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带正电荷的残基是膜蛋白拓扑结构的重要决定因素。

Positively charged residues are important determinants of membrane protein topology.

作者信息

Dalbey R E

机构信息

Department of Chemistry, Ohio State University, Columbus 43210.

出版信息

Trends Biochem Sci. 1990 Jul;15(7):253-7. doi: 10.1016/0968-0004(90)90047-f.

DOI:10.1016/0968-0004(90)90047-f
PMID:2200169
Abstract

Membrane proteins are found in a variety of conformations, with each protein spanning the membrane a set number of times and adopting a particular orientation. Positively charged residues, often located near the boundaries of transmembrane segments, appear to be involved in specifying the topology of membrane proteins.

摘要

膜蛋白具有多种构象，每种蛋白跨膜一定次数并采取特定的取向。带正电荷的残基通常位于跨膜片段的边界附近，似乎参与确定膜蛋白的拓扑结构。

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Positively charged residues are important determinants of membrane protein topology.带正电荷的残基是膜蛋白拓扑结构的重要决定因素。
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