Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
Department of Nutrition, Faculty of Medicine.
Int J Dermatol. 2011 Nov;50(11):1343-1346. doi: 10.1111/j.1365-4632.2011.04968.x.
The role of nutritional factors including trace elements has been reported in the pathogenesis of many autoimmune diseases.
Regarding the relatively high prevalence of pemphigus vulgaris in Iran, we investigated the serum levels of zinc and copper as two important trace elements, together with the oxidative stress status in patients with pemphigus vulgaris.
This case-control study was performed on 25 patients with newly diagnosed pemphigus vulgaris and 25 age- and sex-matched healthy control subjects. Serum concentrations of zinc, copper, ceruloplasmin as well as copper/zinc ratio were determined for each subject. Oxidative stress was also measured using a novel assay of peroxidant-antioxidant balance (PAB).
Mean serum concentrations of zinc and copper as well as copper/zinc ratio were significantly lower in patients (mean age: 47.2±16.2 years; male/female: 14/11) compared with the controls (mean age: 47.3±12.8 years; male/female: 14/11; P<0.001). In contrast, PAB values were significantly elevated in patients compared with controls (P<0.01). No significant difference in serum ceruloplasmin concentrations was observed between the groups (P>0.05).
Our findings indicate that low serum zinc and copper and increased oxidative stress may be associated with pemphigus vulgaris.
营养因素（包括微量元素）在许多自身免疫性疾病的发病机制中发挥作用已得到报道。
鉴于寻常型天疱疮在伊朗的高发病率，我们研究了锌和铜这两种重要微量元素以及寻常型天疱疮患者的氧化应激状态在其中的血清水平。
本病例对照研究纳入了 25 例新诊断的寻常型天疱疮患者和 25 名年龄和性别相匹配的健康对照者。对每位受试者测定了血清锌、铜、铜蓝蛋白以及铜/锌比值。还使用一种新的氧化还原平衡（PAB）测定法来评估氧化应激。
患者（平均年龄：47.2±16.2 岁；男/女：14/11）的血清锌和铜以及铜/锌比值均明显低于对照组（平均年龄：47.3±12.8 岁；男/女：14/11；P<0.001）。相比之下，患者的 PAB 值明显高于对照组（P<0.01）。两组间血清铜蓝蛋白浓度无显著差异（P>0.05）。
我们的研究结果表明，血清锌和铜水平降低以及氧化应激增加可能与寻常型天疱疮相关。
