Yu Wen-Kuang, Chen Yen-Wen, Shie Huei-Guan, Lien Te-Cheng, Kao Hsin-Kuo, Wang Jia-Horng
Department of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, Taiwan.
J Cardiothorac Surg. 2011 Oct 17;6:141. doi: 10.1186/1749-8090-6-141.
A retrospective study to evaluate the effect of hyperbaric oxygen (HBO2) therapy on sternal infection and osteomyelitis following median sternotomy.
A retrospective analysis of patients who received sternotomy and cardiothoracic surgery which developed sternal infection and osteomyelitis between 2002 and 2009. Twelve patients who received debridement and antibiotic treatment were selected, and six of them received additional HBO2 therapy. Demographic, clinical characteristics and outcome were compared between patients with and without HBO2 therapy.
HBO2 therapy did not cause any treatment-related complication in patients receiving this additional treatment. Comparisons of the data between two study groups revealed that the length of stay in ICU (8.7 ± 2.7 days vs. 48.8 ± 10.5 days, p < 0.05), duration of invasive (4 ± 1.5 days vs. 34.8 ± 8.3 days, p < 0.05) and non-invasive (4 ± 1.9 days vs. 22.3 ± 6.2 days, p < 0.05) positive pressure ventilation were all significantly lower in patients with additional HBO2 therapy, as compared to patients without HBO2 therapy. Hospital mortality was also significantly lower in patients who received HBO2 therapy (0 case vs. 3 cases, p < 0.05), as compared to patients without the HBO2 therapy.
In addition to primary treatment with debridement and antibiotic use, HBO2 therapy may be used as an adjunctive and safe treatment to improve clinical outcomes in patients with sternal infection and osteomyelitis after sternotomy and cardiothoracic surgery.
进行一项回顾性研究，以评估高压氧（HBO₂）治疗对正中开胸术后胸骨感染和骨髓炎的影响。
对2002年至2009年间接受开胸心脏手术且发生胸骨感染和骨髓炎的患者进行回顾性分析。选取12例接受清创和抗生素治疗的患者，其中6例还接受了额外的HBO₂治疗。比较接受和未接受HBO₂治疗患者的人口统计学、临床特征及预后。
接受额外HBO₂治疗的患者未出现任何与治疗相关的并发症。两组研究数据比较显示，与未接受HBO₂治疗的患者相比，接受额外HBO₂治疗患者的重症监护病房（ICU）住院时间（8.7±2.7天 vs. 48.8±10.5天，p<0.05）、有创（4±1.5天 vs. 34.8±8.3天，p<0.05）和无创（4±1.9天 vs. 22.3±6.2天，p<0.05）正压通气持续时间均显著缩短。接受HBO₂治疗患者的医院死亡率也显著低于未接受HBO₂治疗的患者（0例 vs. 3例，p<0.05）。
除了清创和使用抗生素的主要治疗外，HBO₂治疗可作为一种辅助性的安全治疗方法，用于改善开胸心脏手术后胸骨感染和骨髓炎患者的临床结局。
