Department of Molecular and Human Genetics, College of Medicine, Florida International University, Miami, FL 33199, USA.
Forensic Sci Int Genet. 2012 Jul;6(4):437-46. doi: 10.1016/j.fsigen.2011.09.002. Epub 2011 Oct 17.
In the present study, we analyzed 17 Y-STR loci in 350 Tibetan males from three culturally defined regions of historical Tibet: Amdo (88), Kham (109) and U-Tsang (153). A total of 299 haplotypes were observed, 272 (90.9%) of which were unique. Only one Y-STR profile is shared across the three Tibetan groups and, incidentally, is also the most frequent haplotype (4.0%), represented by two, five and seven individuals from U-Tsang, Kham and Amdo, respectively. The overall haplotype diversity for the three Tibetan populations at 17 Y-STR loci was 0.9978 and the corresponding values for the extended (11-loci) and minimal (9-loci) haplotypes were 0.9935 and 0.9909, respectively. Both neighbor-joining and Rst pairwise analyses suggest a close genetic relationship between the Amdo and Kham populations, while U-Tsang is genetically distinct from the aforementioned groups. The results demonstrate that the 17 Y-STR loci analyzed are highly polymorphic in all three Tibetan populations examined and hence useful for forensic cases, paternity testing and population genetic studies.
在本研究中，我们分析了来自历史上藏区三个文化界定区域的 350 名藏族男性的 17 个 Y-STR 基因座：安多（88）、康巴（109）和卫藏（153）。共观察到 299 种单倍型，其中 272 种（90.9%）是独特的。三个藏族群体之间仅共享一个 Y-STR 图谱，巧合的是，这也是最常见的单倍型（4.0%），分别由来自卫藏、康巴和安多的两个人、五个人和七个人代表。在 17 个 Y-STR 基因座上，三个藏族群体的总体单倍型多样性为 0.9978，扩展（11 个基因座）和最小（9 个基因座）单倍型的相应值分别为 0.9935 和 0.9909。邻接和 Rst 成对分析均表明，安多和康巴群体之间存在密切的遗传关系，而卫藏则与上述群体在遗传上存在差异。结果表明，在所研究的三个藏族群体中，17 个 Y-STR 基因座高度多态性，因此可用于法医案件、亲子关系测试和群体遗传学研究。
