Department of Forensic Psychiatry, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
Department of Forensic Toxicological Analysis, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, 8Th Floor, Fa Yi Building, No.16, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan, China.
Int J Legal Med. 2021 Sep;135(5):1793-1795. doi: 10.1007/s00414-021-02611-1. Epub 2021 Apr 27.
Y-Chromosomal short-tandem repeats (Y-STRs) could provide highly valuable information for forensic investigation and demographic studies. However, there is still no systematic Y-STR information on Tibetan as obtained from different regions of the broad Qinghai-Tibet Plateau. In this study, an analysis was conducted on 585 male individuals, classed into 3 different dialect branches as Ü-Tsang, Amdo, and Khams and originating from 11 scattered regions of the Qinghai-Tibet Plateau. The gene diversity values of the 41 Y-STRs in Tibetan ranged from 0.3636 to 0.9322. Additionally, a total of 563 distinct haplotypes were obtained with an overall haplotype diversity of 0.9999 and a discrimination capacity of 0.9624. As suggested by the inter-population diversity analysis, there were two main separated clades of Tibetan subgroups. The visualization of pairwise genetic distances between 11 Tibetan subgroups and 59 reference populations using cladogram revealed the distribution of various populations, which was basically consistent with the patterns of geographic origin and linguistic affinity.
Y 染色体短串联重复序列（Y-STRs）可为法医学调查和人口研究提供极具价值的信息。然而，目前仍缺乏来自青藏高原不同地区的藏族人群的系统 Y-STR 信息。本研究对来自青藏高原 11 个分散地区的 3 个不同方言分支（卫藏、安多和康巴）的 585 名男性个体进行了分析。藏族人群的 41 个 Y-STR 的基因多样性值范围为 0.3636 至 0.9322。此外，共获得了 563 个独特单倍型，总体单倍型多样性为 0.9999，鉴别能力为 0.9624。种群间多样性分析表明，藏族人群存在两个主要的分支聚类。通过聚类图显示的 11 个藏族亚群与 59 个参考群体之间的成对遗传距离可视化，揭示了不同群体的分布情况，这基本与地理起源和语言亲缘关系的模式一致。
