Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo, 113-8655, Japan,
Brain Imaging Behav. 2009 Sep;3(3):277-83. doi: 10.1007/s11682-009-9069-0. Epub 2009 May 14.
Thought disorder is considered as one of the core features of schizophrenia and several research groups previously reported an association between P300 (P3b) amplitude and thought disorder in schizophrenia. However, previous studies have not evaluated two P300 subcomponents (P3a and P3b) to investigate whether the relationship with thought disorder was specific to P3b. In this study, we measured P3b and thought disorder of 60 patients with schizophrenia. We also measured P3a of 36 patients out of this sample. We replicated correlation between P3b amplitude and thought disorder and extended this finding by observing that this correlation was not present for the P3a subcomponent. These results suggest that specific electrophysiological abnormalities associated with context updating may underlie thought disorder in schizophrenia.
思维障碍被认为是精神分裂症的核心特征之一，有几个研究小组此前曾报告过 P300（P3b）振幅与精神分裂症思维障碍之间的关联。然而，以前的研究并未评估 P300 的两个子成分（P3a 和 P3b），以探究与思维障碍的关系是否特定于 P3b。在这项研究中，我们测量了 60 名精神分裂症患者的 P3b 和思维障碍，还测量了该样本中 36 名患者的 P3a。我们复制了 P3b 振幅与思维障碍之间的相关性，并通过观察到 P3a 子成分不存在这种相关性，扩展了这一发现。这些结果表明，与上下文更新相关的特定电生理异常可能是精神分裂症思维障碍的基础。
